| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-76 |
DRI_Outcome |
denotes |
Cullin-3 protein expression levels correlate with breast cancer progression. |
| T2 |
77-212 |
DRI_Challenge |
denotes |
Cullin-3 is a component of the Cullin-Ring ubiquitin ligase (CRL) family that plays an important role in mediating protein degradation. |
| T3 |
213-370 |
DRI_Background |
denotes |
Deregulation of Cullin-3 expression has been observed in human cancers; however, a role for Cullin-3 in tumor progression has not been previously recognized. |
| T4 |
371-566 |
DRI_Outcome |
denotes |
Using the MCF10DCIS.com human breast cancer xenograft model, we show that Cullin-3 is increasingly expressed during progression from comedo ductal carcinoma in situ (DCIS) to invasive carcinomas. |
| T5 |
567-712 |
DRI_Background |
denotes |
Cullin-3 protein is not detected in early lesions but is noticeably increased in DCIS tumors and significantly overexpressed in invasive cancers. |
| T6 |
713-806 |
DRI_Background |
denotes |
In experimental metastasis assays, high expression of Cullin-3 was observed in the lung site. |
| T7 |
807-975 |
DRI_Outcome |
denotes |
Importantly, Cullin-3 staining is detected in human breast cancer tissues, not in normal breast tissues and its expression level positively correlates with tumor stage. |
| T8 |
976-1161 |
DRI_Approach |
denotes |
These data suggest that Cullin-3 may play an important role in tumor progression from DCIS to invasive cancer and may serve as a biomarker for the diagnosis of aggressive breast cancer. |
