UseCases_ArguminSci_Discourse  

PubMed:22592643 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-8 REPLACED denotes Apocynum
T2 9-16 Token_Label.OUTSIDE denotes venetum
T3 17-184 DRI_Outcome denotes leaf extract attenuates disruption of the blood-brain barrier and upregulation of matrix metalloproteinase-9/-2 in a rat model of cerebral ischemia-reperfusion injury.
T4 185-231 DRI_Outcome denotes We investigated the neuroprotective effects of
T5 232-248 Token_Label.OUTSIDE denotes Apocynum venetum
T6 249-363 DRI_Outcome denotes leaf extract (AVLE) on a rat model of cerebral ischemia-reperfusion injury and explored the underlying mechanisms.
T7 364-467 DRI_Background denotes Rats were randomly divided into five groups: sham, ischemia-reperfusion, AVLE125, AVLE250, and AVLE500.
T8 468-550 DRI_Background denotes Cerebral ischemia was induced by 1.5 h of occlusion of the middle cerebral artery.
T9 551-721 DRI_Background denotes Cerebral infarct area was measured by tetrazolium staining at 24 and 72 h after reperfusion, and neurological function was evaluated at 24, 48 and 72 h after reperfusion.
T10 722-848 DRI_Background denotes Pathological changes on the ultrastructure of the blood-brain barrier (BBB) were observed by transmission electron microscopy.
T11 849-940 DRI_Background denotes BBB permeability was assessed by detecting leakage of Evan's blue (EB) dye in brain tissue.
T12 941-1098 DRI_Background denotes The expression and activities of matrix metalloproteinase (MMP)-9/-2 were measured by western blot analyses and gelatin zymography at 24 h after reperfusion.
T13 1099-1362 DRI_Approach denotes AVLE (500 mg/kg/day) significantly reduced cerebral infarct area, improved recovery of neurological function, relieved morphological damage to the BBB, reduced water content and EB leakage in the brain, and downregulated the expression and activities of MMP-9/-2.
T14 1363-1488 DRI_Challenge denotes These findings suggest that AVLE protects against cerebral ischemia-reperfusion-induced injury by alleviating BBB disruption.
T15 1489-1583 DRI_Outcome denotes This action may be due to its inhibitory effects on the expression and activities of MMP-9/-2.