UseCases_ArguminSci_Discourse  

PubMed:22315971 JSONTXT 12 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-190 DRI_Background denotes Redox proteomics analyses of the influence of co-expression of wild-type or mutated LRRK2 and Tau on C. elegans protein expression and oxidative modification: relevance to Parkinson disease.
T2 197-344 DRI_Background denotes The human LRRK2 gene has been identified as the most common causative gene of autosomal-dominantly inherited and idiopathic Parkinson disease (PD).
T3 345-406 DRI_Approach denotes The G2019S substitution is the most common mutation in LRRK2.
T4 407-488 DRI_Background denotes The R1441C mutation also occurs in cases of familial PD, but is not as prevalent.
T5 489-625 DRI_Outcome denotes Some cases of LRRK2-based PD exhibit Tau pathology, which suggests that alterations on LRRK2 activity affect the pathophysiology of Tau.
T6 626-829 DRI_Outcome denotes To investigate how LRRK2 might affect Tau and the pathophysiology of PD, we generated lines of C. elegans expressing human LRRK2 [wild-type (WT) or mutated (G2019S or R1441C)] with and without V337M Tau.
T7 830-971 DRI_Background denotes Expression and redox proteomics were used to identify the effects of LRRK2 (WT and mutant) on protein expression and oxidative modifications.
T8 981-1196 DRI_Background denotes Co-expression of WT LRRK2 and Tau led to increased expression of numerous proteins, including several 60S ribosomal proteins, mitochondrial proteins, and the V-type proton ATPase, which is associated with autophagy.
T9 1197-1355 DRI_Background denotes C. elegans expressing mutant LRRK2 showed similar changes, but also showed increased protein oxidation and lipid peroxidation, the latter indexed as increased
T10 1356-1389 Token_Label.OUTSIDE denotes protein-bound 4-hydroxy-2-nonenal
T11 1390-1396 DRI_Background denotes (HNE).
T12 1409-1620 DRI_Challenge denotes Our study brings new knowledge about the possible alterations induced by LRRK2 (WT and mutated) and Tau interactions, suggesting the involvement of G2019S and R1441C in Tau-dependent neurodegenerative processes.
T13 1633-1792 DRI_Background denotes These results suggest that changes in LRRK2 expression or activity lead to corresponding changes in mitochondrial function, autophagy, and protein translation.
T14 1793-1866 DRI_Background denotes These findings are discussed with reference to the pathophysiology of PD.