UseCases_ArguminSci_Discourse  

PubMed:21698001 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-76 DRI_Background denotes Temporal expression of mutant LRRK2 in adult rats impairs dopamine reuptake.
T2 77-164 DRI_Background denotes Parkinson's disease (PD) results from progressive degeneration of dopaminergic neurons.
T3 165-251 DRI_Outcome denotes Most PD cases are sporadic, but some have pathogenic mutation in the individual genes.
T4 252-393 DRI_Approach denotes Mutation of the leucine-rich repeat kinase-2 (LRRK2) gene is associated with familial and sporadic PD, as exemplified by G2019S substitution.
T5 394-606 DRI_Challenge denotes While constitutive expression of mutant LRRK2 in transgenic mice fails to induce neuron death, transient expression of the disease gene by viral delivery causes a substantial loss of dopaminergic neurons in mice.
T6 607-730 DRI_Outcome denotes To further assess LRRK2 pathogenesis, we created inducible transgenic rats expressing human LRRK2 with G2019S substitution.
T7 731-994 DRI_Background denotes Temporal overexpression of LRRK2(G2019S) in adult rats impaired dopamine reuptake by dopamine transporter (DAT) and thus enhanced locomotor activity, the phenotypes that were not observed in transgenic rats constitutively expressing the gene throughout life time.
T8 995-1132 DRI_Background denotes Reduced DAT binding activity is an early sign of dopaminergic dysfunction in asymptomatic subjects carrying pathogenic mutation in LRRK2.
T9 1133-1257 DRI_Outcome denotes Our transgenic rats recapitulated the initiation process of dopaminergic dysfunction caused by pathogenic mutation in LRRK2.
T10 1258-1392 DRI_Background denotes Inducible transgenic approach uncovered phenotypes that may be obscured by developmental compensation in constitutive transgenic rats.
T11 1393-1645 DRI_Background denotes Finding in inducible LRRK2 transgenic rats would guide developing effective strategy in transgenic studies: Inducible expression of transgene may induce greater phenotypes than constitutive gene expression, particularly in rodents with short life time.