UseCases_ArguminSci_Discourse  

PubMed:19118538 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-66 DRI_Challenge denotes NMDA preconditioning and neuroprotection in vivo: delayed onset of
T2 67-86 Token_Label.OUTSIDE denotes kainic acid-induced
T3 87-143 DRI_Challenge denotes neurodegeneration and c-Fos attenuation in CA3a neurons.
T4 144-169 DRI_Unspecified denotes Intraventricular (i.c.v.)
T5 170-262 DRI_Background denotes kainic acid (KA) causes an acute excitotoxic lesion to the CA3 region of rodent hippocampus.
T6 263-373 DRI_Background denotes Recent evidence implicated c-fos gene in regulating neuron survival and death following an excitotoxic insult.
T7 374-535 DRI_Approach denotes In this study we attempted to prevent KA-induced damage in CA3 neurons with NMDA preconditioning, which produced a marked expression of c-fos in the hippocampus.
T8 536-542 DRI_Unspecified denotes NMDA (
T9 542-554 Token_Label.OUTSIDE denotes 0.6-6 microg
T10 554-563 DRI_Unspecified denotes , i.c.v.)
T11 564-643 DRI_Background denotes was injected to anesthetized rats alone or 1 h before KA (0.15 microg, i.c.v.).
T12 644-747 DRI_Approach denotes Following KA injection, vibratome sections were processed for immunohistochemistry/electron microscopy.
T13 748-854 DRI_Approach denotes c-Fos and Nissl staining were used to estimate the extent of neuronal excitation and damage, respectively.
T14 855-1004 DRI_Approach denotes Quantitative evaluation of c-Fos-labeled cells showed significantly less c-Fos in CA3a than in neighboring CA3b and CA2 from 1 to 4 h after KA alone.
T15 1005-1121 DRI_Challenge denotes Attenuation of expressed c-Fos in CA3a was accompanied by damage of neurons with more apoptotic than necrotic signs.
T16 1122-1229 DRI_Approach denotes NMDA preconditioning elevated CA3a c-Fos expression and at 1 and 2 h exceeded markedly that after KA alone.
T17 1230-1357 DRI_Approach denotes However, at 4 h after KA, NMDA-preconditioned c-Fos induction in CA3a diminished to the same level as that seen after KA alone.
T18 1358-1420 DRI_Challenge denotes The onset of neuronal degeneration was delayed in similar way.
T19 1421-1608 DRI_Outcome denotes While NMDA-induced c-Fos expression in CA3a could be blocked by MK-801 completely, MK-801 and CNQX were both without significant effect on KA-induced c-Fos expression and neuronal damage.
T20 1609-1757 DRI_Outcome denotes In conclusion, inhibition of c-Fos expression and onset of neuronal damage in CA3a following icv KA injection might be transiently delayed by i.c.v.
T21 1758-1779 DRI_Unspecified denotes NMDA preconditioning.