UseCases_ArguminSci_Discourse  

PubMed:17184751 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-110 DRI_Background denotes Diphenyleneiodonium and dimethylsulfoxide for treatment of reperfusion injury in cerebral ischemia of the rat.
T2 111-199 DRI_Background denotes Diphenyleneiodonium (DPI) is an inhibitor of the free radical producing NAD(P)H-oxidase.
T3 200-374 DRI_Approach denotes We tested whether DPI shows neuroprotective properties after focal cerebral ischemia and we used dimethylsulfoxide (DMSO), a nonspecific free radical scavenger, as a solvent.
T4 375-515 DRI_Background denotes In male Wistar rats middle cerebral artery occlusion (1.5 h) and subsequent reperfusion (48 h) (MCAO/R) was induced with the filament model.
T5 516-672 DRI_Background denotes Immediately after reperfusion the animals received either 0.25 ml normal saline, DMSO, or a combination of DMSO and DPI; each group consisted of 10 animals.
T6 673-728 DRI_Outcome denotes MRI was performed at different times after reperfusion.
T7 729-799 DRI_Background denotes Gelatine zymography of brain tissue for MMP-2 and MMP-9 was performed.
T8 800-952 DRI_Outcome denotes The infarct sizes and BBB damage showed a significant difference between controls and the DPI/DMSO group for almost all points in time in all sequences.
T9 953-1045 DRI_Background denotes The activity of MMP-2 and MMP-9 was significantly reduced by DPI/DMSO but not by DMSO alone.
T10 1046-1225 DRI_Background denotes DMSO treatment alone resulted in a protective effect with reduced lesion sizes measured by MRI at selected points of time, consistent with its known free radical scavenger effect.
T11 1226-1359 DRI_Challenge denotes The combination of DMSO with DPI partly augmented this effect, presumably due to the additional inhibition of MMP-2 and MMP-9 by DPI.
T12 1360-1543 DRI_Outcome denotes Moreover, the neurological outcome in both therapeutic groups was improved compared to controls with a significant difference between the therapeutic groups in favour of DPI and DMSO.
T13 1544-1706 DRI_Outcome denotes The combination of DPI and DMSO reduced the activity of MMP-2 and MMP-9, attenuated the postischemic blood-brain barrier damage and improved neurological outcome.
T14 1707-1760 DRI_Background denotes This was most likely due to reduced oxidative stress.