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UseCases_ArguminSci_Discourse

PubMed:16489579 JSON TXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T1	0-98	DRI_Approach	denotes	Preferential expression of matrix metalloproteinase-9 in mouse skin after sulfur mustard exposure.
T2	99-276	DRI_Approach	denotes	Matrix metalloproteinases (MMPs), a class of enzymes responsible for the degradation of extracellular matrix proteins, play important roles in inflammatory and immune responses.
T3	277-396	DRI_Background	denotes	In skin, MMP-2 (gelatinase A) and MMP-9 (gelatinase B) are normally inactive but can be expressed during tissue injury.
T4	397-527	DRI_Approach	denotes	Both degrade collagen IV and other critical components of the basement membrane zone that separates the epidermis from the dermis.
T5	528-671	DRI_Background	denotes	The expression of MMP-2 and -9 was studied in sulfur mustard (SM)-exposed ear skin from mice to determine their role in tissue vesicant injury.
T6	672-797	DRI_Background	denotes	Punch biopsies of mouse ears were collected between 6 and 168 h after exposure to 97.5 mM (0.08 mg) SM diluted in CH(2)Cl(2).
T7	798-987	DRI_Background	denotes	They were examined histologically and assayed for MMP-2 and -9 expression by gelatinase activity assays, real-time reverse transcriptase-polymerase chain reaction and Western blot analysis.
T8	988-1075	DRI_Outcome	denotes	A time-related increase in overall gelatinase activity was observed in SM-treated ears.
T9	1076-1243	DRI_Approach	denotes	At 168 h after SM exposure, the relative levels of MMP-9 mRNA were increased 27-fold and MMP-9 protein 9-fold when compared with the control (CH(2)Cl(2) treated) ears.
T10	1244-1361	DRI_Background	denotes	In contrast, there were no observable increases in the MMP-2 mRNA or protein levels between treated and control ears.
T11	1362-1526	DRI_Approach	denotes	These observations suggest the differential expression of MMP-2 and -9 during the cutaneous response to SM injury and suggest a role for MMP-9 in SM-induced injury.