UseCases_ArguminSci_Discourse  

PubMed:16292950 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-167 DRI_Background denotes Reflectance confocal microscopy for characterization of mammary ductal structures and development of neoplasia in genetically engineered mouse models of breast cancer.
T2 168-255 DRI_Background denotes The earliest steps of breast cancer begin with aberrations in mammary ductal structure.
T3 256-470 DRI_Background denotes Techniques that enable an investigator to image in situ and then analyze the same tissue using biochemical tools facilitates identification of genetic networks and signaling pathways active in the imaged structure.
T4 471-776 DRI_Background denotes Cellular confocal microscopy (VivaCell-TiBa, Rochester, New York) is used to image mammary ductal structures and surrounding vasculature in situ in intact wild-type and genetically engineered mice that develop ER alpha-initiated ductal carcinoma in situ (DCIS) and ER alpha-driven invasive mammary cancer.
T5 777-958 DRI_Background denotes In wild-type mice, normal mammary ductal structures that appear from puberty through lactation are visualized and serially sectioned optically, and a developmental atlas is created.
T6 959-1062 DRI_Background denotes Altering tissue preparation enabled visualization of the vasculature surrounding the ductal structures.
T7 1063-1205 DRI_Background denotes In the genetically engineered mice, aberrant mammary ductal structures and cancers are imaged and compared to corresponding normal structures.
T8 1206-1319 DRI_Background denotes Different preparation techniques are able to preserve tissue for routine histological analyses and RNA isolation.
T9 1320-1542 DRI_Background denotes Comparative studies demonstrate that reflectance confocal imaging provides more cellular detail than carmine-alum-stained mammary gland whole mounts and equivalent detail with hematoxylin and eosin stained tissue sections.
T10 1543-1672 DRI_Challenge denotes In summary, reflectance confocal microscopy is a tool that can be used to rapidly and accurately analyze mammary gland structure.