| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-189 |
DRI_Background |
denotes |
Expression of Her2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive mammary ductal carcinoma associated with ductal carcinoma In Situ (DCIS) Versus invasive breast cancer alone. |
| T2 |
196-487 |
DRI_Approach |
denotes |
(a) To assess the expression patterns of HER2/neu, steroid receptors (ER and PR), Ki67 and p53 in invasive ductal cancer (IDC) and IDC associated with carcinoma in situ (IDC/DCIS) and (b) to determine if there is a differential expression of these molecular markers between IDC and IDC/DCIS. |
| T3 |
511-678 |
DRI_Background |
denotes |
Paraffin-fixed breast cancer samples, diagnosed with only one histological invasive tumor (IDC (n=130), and IDC/DCIS (n=36) were analyzed by immunohistochemical means. |
| T4 |
679-801 |
DRI_Approach |
denotes |
The non-parametric Mann-Whitney and chi2 tests were used to evaluate any statistical differences between different groups. |
| T5 |
802-837 |
DRI_Unspecified |
denotes |
Significance was assumed at p<0.05. |
| T6 |
847-938 |
DRI_Unspecified |
denotes |
A significant increase of the tumor grading was observed between IDC and IDC/DCIS (p<0.05). |
| T7 |
939-1032 |
DRI_Unspecified |
denotes |
Her2/neu amplification was demonstrated in 49.6% of IDC compared to 31% of IDC/DCIS (p<0.05). |
| T8 |
1033-1106 |
DRI_Approach |
denotes |
ER expression showed no statistical differences between IDC and IDC/DCIS. |
| T9 |
1107-1214 |
DRI_Outcome |
denotes |
The PR expression was demonstrated in 71% of IDC with significantly lower intensity than IDC/DCIS (p<0.05). |
| T10 |
1215-1312 |
DRI_Outcome |
denotes |
The Ki67 expression was significantly higher (p<0.05) in IDC cases (64%) versus IDC/DCIS (49.7%). |
| T11 |
1313-1386 |
DRI_Approach |
denotes |
No differences were observed between IDC and IDC/DCIS for p53 expression. |
| T12 |
1399-1507 |
DRI_Outcome |
denotes |
We demonstrated significantly different expression patterns of Her2/neu, PR and Ki67 in IDC versus IDC/DCIS. |
| T13 |
1508-1673 |
DRI_Challenge |
denotes |
Since these molecular markers play important roles in carcinogenesis and tumor progression, IDC/DCIS could be an important subtype of mammary invasive ductal cancer. |
| T14 |
1674-1797 |
DRI_Challenge |
denotes |
Differences in expression of the evaluated markers might suggest a higher malignant potential of invasive carcinomas alone. |
| T15 |
1798-1927 |
DRI_Outcome |
denotes |
The lower expression of Her2/neu and Ki67 in IDC/DCIS could implicate a less malignant behavior compared to a differentiated IDC. |
| T16 |
1928-2105 |
DRI_Challenge |
denotes |
Additionally, these results might suggest that DCIS might be a malignant preform and the interaction with neoplastic tissue could result in an aggressive type of invasive tumor. |
