UseCases_ArguminSci_Discourse  

PubMed:12874968 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-39 DRI_Background denotes Carcinoma in situ of the female breast.
T2 40-105 DRI_Unspecified denotes A clinico-pathological, immunohistological, and DNA ploidy study.
T3 106-264 DRI_Background denotes Carcinoma in situ of the breast (CIS) comprise a heterogenous group of lesions, covering a wide spectrum of clinical conditions and histopathological changes.
T4 265-465 DRI_Challenge denotes With respect to biological behavior, CIS range from biologically aggressive lesions with a substantial risk of progression into invasive carcinoma (IC), to lesions with a very low malignant potential.
T5 466-572 DRI_Background denotes Two main types of CIS are described--ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS).
T6 573-662 DRI_Background denotes Previous studies of CIS indicate that approximately a third will subsequently develop IC.
T7 663-803 DRI_Background denotes Autopsy studies indicate that CIS is frequently occurring and it was estimated that about 20% of all women will develop CIS during lifetime.
T8 804-935 DRI_Background denotes Only a minor fraction is ever diagnosed, although the incidence of DCIS is increasing, especially related to mammography screening.
T9 936-1066 DRI_Background denotes The lack of knowledge about the biological significance of the histopathological subtypes was the background of the present study.
T10 1067-1124 DRI_Unspecified denotes In 1982, a nationwide, prospective study of CIS (protocol
T11 1125-1135 Token_Label.OUTSIDE denotes DBCG 82-IS
T12 1135-1204 DRI_Unspecified denotes ) was initiated by the Danish Breast Cancer Cooperative Group (DBCG).
T13 1205-1358 DRI_Approach denotes From this protocol, the group of patients treated with breast conservation surgery (BCS) constituted the material for clinico-histological investigation.
T14 1359-1416 DRI_Background denotes A total of 275 women were included in the period 1982-89.
T15 1417-1527 DRI_Unspecified denotes Follow-up studies showed that recurrence rate was significantly related to nuclear size of the primary lesion.
T16 1528-1748 DRI_Background denotes Since nuclear changes might be related to DNA content and, furthermore, many invasive breast carcinomas were shown to be DNA aneuploid, flow cytometric (FCM) DNA ploidy analysis was performed in a series of DCIS lesions.
T17 1749-1865 DRI_Outcome denotes More than 80% of these lesions were DNA aneuploid, with a distribution similar to that found in invasive carcinomas.
T18 1866-2004 DRI_Outcome denotes This finding raised the hypothesis that the DNA pattern of an invasive carcinoma was already established at the preinvasive stage of DCIS.
T19 2005-2092 DRI_Approach denotes Therefore, FCM DNA analysis was performed on a series of ICs with predominance of DCIS.
T20 2093-2358 DRI_Approach denotes Partial or complete concordance in DNA ploidy between DCIS and IC within the individual case was found in most cases, except for the additional presence in the IC component of DNA hyperdiploid clones that might possibly be of importance for the process of invasion.
T21 2359-2576 DRI_Approach denotes In order to further characterize CIS lesions and, possibly, to discriminate biologically different groups, immunohistochemical markers were investigated in a consecutive series of CIS and IC with predominance of DCIS.
T22 2577-2654 DRI_Outcome denotes The results were correlated to the histopathological and DNA ploidy findings.
T23 2655-2957 DRI_Outcome denotes In DCIS, significant correlation was shown between large nuclear size and comedonecrosis, both of which showed also strong association to DNA aneuploidy, high proliferation activity, low steroid receptor content, and overexpression of c-erbB-2 and p53--factors that may indicate an aggressive behavior.
T24 2958-3112 DRI_Approach denotes Small nuclear CIS, whether LCIS or DCIS, on the contrary, were DNA diploid with low proliferation, and no cases showed overexpression of c-erbB-2 and p53.
T25 3113-3194 DRI_Outcome denotes In IC, comparison of the DCIS and the invasive component showed similar patterns.
T26 3195-3334 DRI_Background denotes No significant differences, in neither morphology, immunohistochemistry, nor DNA ploidy, were shown between DCIS without and with invasion.
T27 3335-3473 DRI_Outcome denotes These findings may indicate that none of the parameters in question may on its own be essential for the decisive event of invasive growth.