| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-110 |
DRI_Challenge |
denotes |
Neuroprotection by memantine, a non-competitive NMDA receptor antagonist after traumatic brain injury in rats. |
| T2 |
111-314 |
DRI_Challenge |
denotes |
This study investigated whether memantine, a non-competitive NMDA receptor antagonist is neuroprotective after traumatic brain injury (TBI) induced in adult rats with a controlled cortical impact device. |
| T3 |
315-450 |
DRI_Background |
denotes |
TBI led to significant neuronal death in the hippocampal CA2 and CA3 regions (by 50 and 59%, respectively), by 7 days after the injury. |
| T4 |
451-507 |
DRI_Background |
denotes |
Treatment of rats with memantine (10 and 20 mg/Kg, i.p.) |
| T5 |
508-607 |
DRI_Outcome |
denotes |
immediately after the injury significantly prevented the neuronal loss in both CA2 and CA3 regions. |
| T6 |
608-726 |
DRI_Challenge |
denotes |
This is the first study showing the neuroprotective potential of memantine to prevent the TBI-induced neuronal damage. |
