UseCases_ArguminSci_Discourse  

PubMed:11404174 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 0-102 DRI_Background denotes Increased matrix metalloproteinase 9 activity and mRNA expression in lung ischemia-reperfusion injury.
T2 109-257 DRI_Challenge denotes IVES: In lung ischemia-reperfusion injury, neutrophil migration from the vasculature to the interstitial spaces plays a major role in tissue injury.
T3 258-393 DRI_Background denotes Degradation of the basement membrane, which is composed of extracellular matrix (ECM) molecules, is necessary for neutrophil migration.
T4 394-500 DRI_Approach denotes Matrix metalloproteinases (MMPs) might play a role in ECM degradation in lung ischemia-reperfusion injury.
T5 501-670 DRI_Approach denotes We evaluated the changes in the activity of MMP-2 and MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) gene expressions using rat lung transplantation models.
T6 680-713 DRI_Approach denotes We divided animals into 4 groups.
T7 714-827 DRI_Approach denotes Groups I and II served as control groups with intact lungs (Group I) and 24-hour cold-preserved lungs (Group II).
T8 828-899 DRI_Background denotes Groups III and IV received lung grafts after 24-hour cold preservation.
T9 900-1002 DRI_Background denotes The recipient animals were sacrificed 1 hour (Group III) or 24 hours (Group IV) after transplantation.
T10 1003-1043 DRI_Approach denotes We evaluated lung injury histologically.
T11 1044-1086 DRI_Approach denotes We assessed MMP activity using zymography.
T12 1087-1208 DRI_Approach denotes We assessed MMP-2, MMP-9, and TIMP-1 gene expression using biplex reverse transcriptase-polymerase chain reaction method.
T13 1218-1284 DRI_Unspecified denotes In Groups III and IV, we noted severe ischemia-reperfusion injury.
T14 1285-1392 DRI_Approach denotes We noted no significant difference in enzyme activity and gene expression of MMP-2 between Groups I and IV.
T15 1393-1486 DRI_Background denotes The MMP-9 activity and gene expression were low during ischemia and increased on reperfusion.
T16 1487-1637 DRI_Background denotes TIMP-1 gene expression was low during ischemia and at the early phase of reperfusion, and showed a dramatic increase at the late phase of reperfusion.
T17 1651-1752 DRI_Approach denotes Matrix metalloproteinase 9, but not MMP-2, may play an important role in ischemia-reperfusion injury.
T18 1753-1848 DRI_Outcome denotes TIMP-1 increases at the late phase of reperfusion and may compensate for the activity of MMP-9.