| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-86 |
DRI_Background |
denotes |
AgNOR analysis of atypical ductal hyperplasia and intraductal carcinoma of the breast. |
| T2 |
92-326 |
DRI_Background |
denotes |
TIVE: To determine the diagnostic and prognostic value of argyrophilic nucleolar organizer regions (AgNORs) in atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and microinvasive ductal carcinoma (MDCA) of the breast. |
| T3 |
336-440 |
DRI_Background |
denotes |
IGN: Image analysis of histologic sections from biopsies of 46 breast ADH and DCIS and 18 cases of MDCA. |
| T4 |
441-557 |
DRI_Background |
denotes |
Determination of morphometric features of cell nuclei and nucleolar organizer regions by using AMBA software system. |
| T5 |
558-712 |
DRI_Approach |
denotes |
Data were compared with the estrogen receptor/progesterone receptor (ER/PR) content as well as with the growth fraction, determined immunohistochemically. |
| T6 |
722-783 |
DRI_Background |
denotes |
AgNOR number and total AgNOR area increased from ADH to DCIS. |
| T7 |
784-853 |
DRI_Outcome |
denotes |
The highest values were recorded in cases of DCIS with microinvasion. |
| T8 |
854-959 |
DRI_Background |
denotes |
Differences between ADH and intraductal or microinvasive ductal carcinoma were statistically significant. |
| T9 |
960-1092 |
DRI_Approach |
denotes |
Within the group of intraductal carcinomas, the lowest values were measured in the solid type and highest values in the comedo type. |
| T10 |
1093-1208 |
DRI_Background |
denotes |
A correlation was found between AgNOR features and growth fraction but not between these features and ER/PR status. |
| T11 |
1221-1377 |
DRI_Background |
denotes |
Selected AgNOR features are relevant for differentiation between ADH and DCIS as well as between low and high grade DCIS and microinvasive ductal carcinoma. |
| T12 |
1378-1524 |
DRI_Background |
denotes |
Therefore, objective and reproducible data obtained by AgNOR analysis may allow better evaluation of the prognostic significance of these lesions. |
