UseCases_ArguminSci_Discourse  

PubMed:10627141 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-110 DRI_Approach denotes Four new mutations in the DNA mismatch repair gene MLH1 in colorectal cancers with microsatellite instability.
T2 111-133 DRI_Unspecified denotes Mutations in brief no.
T3 134-138 DRI_Unspecified denotes 157.
T4 139-146 DRI_Unspecified denotes Online.
T5 147-287 DRI_Background denotes Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with inherited mutation in one of four DNA mismatch repair genes.
T6 288-382 DRI_Background denotes Somatic mutations in the same genes are also found in a subset of sporadic colorectal cancers.
T7 383-468 DRI_Approach denotes A defect in DNA mismatch repair results in a RER (replication error) tumor phenotype.
T8 469-565 DRI_Approach denotes We screened 110 archival and 11 prospectively acquired colorectal cancers for the RER phenotype.
T9 566-606 DRI_Background denotes A total of 22 cancers were RER-positive.
T10 607-758 DRI_Approach denotes RER-positive tumors were investigated for mutations in the DNA mismatch repair gene MLH1 using single-strand-conformation-polymorphism (SSCP) analysis.
T11 759-837 DRI_Approach denotes We identified four previously undescribed mutations in four different samples.
T12 838-1140 DRI_Approach denotes Three mutations were exonic: a point mutation at codon 69 (AGG-->AAG(arg-->lys]); a single base pair deletion at codon 42/43 (GCAAAATCC-->GCAAATCC) leading to a new stop codon downstream; and a point mutation at codon 757 (TAA-->TAT [termination-->tyr] which extend the MLH1 peptide by 36 ammino acids.
T13 1141-1254 DRI_Approach denotes The fourth mutation was a 1 base pair insertion six base pairs 5' to the start of exon 14 (tttgtttt-->tttggtttt).
T14 1255-1319 DRI_Approach denotes The mutations were not seen in the patients' constitutional DNA.
T15 1320-1414 DRI_Background denotes The somatic MLHI mutations identified appear to be causally associated with the RER phenotype.