UseCases_ArguminSci_Discourse  

PubMed:10615123 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-86 DRI_Outcome denotes MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
T2 87-244 DRI_Challenge denotes DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non-polyposis colon cancer (HNPCC).
T3 245-380 DRI_Approach denotes To identify new human mismatch repair proteins, we probed nuclear extracts with the conserved carboxy-terminal MLH1 interaction domain.
T4 381-522 DRI_Outcome denotes Here we describe the cloning and complete genomic sequence of MLH3, which encodes a new DNA mismatch repair protein that interacts with MLH1.
T5 523-734 DRI_Background denotes MLH3 is more similar to mismatch repair proteins from yeast, plants, worms and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans.
T6 735-771 DRI_Background denotes Cells in culture stably expressing a
T7 772-794 Token_Label.OUTSIDE denotes dominant-negative MLH3
T8 795-838 DRI_Background denotes protein exhibit microsatellite instability.
T9 839-985 DRI_Background denotes Mlh3 is highly expressed in gastrointestinal epithelium and physically maps to the mouse complex trait locus colon cancer susceptibility I (Ccs1).
T10 986-1121 DRI_Approach denotes Although we were unable to identify a mutation in the protein-coding region of Mlh3 in the susceptible mouse strain, colon tumours from
T11 1122-1135 Token_Label.OUTSIDE denotes congenic Ccs1
T12 1136-1176 DRI_Approach denotes mice exhibit microsatellite instability.
T13 1177-1369 DRI_Background denotes Functional redundancy among Mlh3, Pms1 and Pms2 may explain why neither Pms1 nor Pms2 mutant mice develop colon cancer, and why PMS1 and PMS2 mutations are only rarely found in HNPCC families.