| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
187-452 |
DRI_Background |
denotes |
Matrix-degrading proteases, including metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs), are involved in modulation of the extracellular matrix, which participates in neural cell differentiation, brain morphogenesis and tissue integrity. |
| T2 |
453-603 |
DRI_Background |
denotes |
Metalloproteinases and TIMPs are associated with inflammatory and degenerative processes in the central nervous system and are regulated by cytokines. |
| T3 |
604-689 |
DRI_Background |
denotes |
Human retroviral infections are frequently associated with neurological disturbances. |
| T4 |
690-923 |
DRI_Outcome |
denotes |
In the present paper, we have studied the changes occurring in human primitive neuroectodermal cells following infection with human T cell lymphotropic virus type 1 (HTLV-I), a retrovirus responsible for HTLV-I-associated myelopathy. |
| T5 |
924-1024 |
DRI_Background |
denotes |
Infected neural cells were found to have high metalloproteinase 9 (MMP9-92 kDa gelatinase) activity. |
| T6 |
1025-1089 |
DRI_Background |
denotes |
MMP9 induction is dependent on HTLV-I infection of neural cells. |
| T7 |
1090-1219 |
DRI_Background |
denotes |
In addition, soluble factors, especially tumour necrosis factor alpha, secreted by infected cells, act as mediators of induction. |
| T8 |
1220-1319 |
DRI_Background |
denotes |
HTLV-I infection also induces expression of RNA coding for tissue inhibitor of metalloproteinase 2. |
| T9 |
1320-1610 |
DRI_Outcome |
denotes |
These observations indicate that HTLV-I infection selectively modulates the expression of molecules involved in the dynamic equilibrium between the synthesis and degradation of the neural cell matrix and leads to its remodelling, which modifies cell-cell interactions and cellular function. |
