| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
112-260 |
DRI_Background |
denotes |
A novel coronavirus disease (COVID-19), caused by infection with SARS-CoV-2, has swept across 31 provinces in China and over 40 countries worldwide. |
| T2 |
261-402 |
DRI_Challenge |
denotes |
The transition from first symptoms to acute respiratory distress syndrome (ARDS) is highly likely to be due to uncontrolled cytokine release. |
| T3 |
403-478 |
DRI_Approach |
denotes |
There is an urgent need to identify safe and effective drugs for treatment. |
| T4 |
536-598 |
DRI_Approach |
denotes |
However, the clinical use of CQ can cause severe side effects. |
| T5 |
599-751 |
DRI_Challenge |
denotes |
We propose that hydroxychloroquine (HCQ), which exhibits an antiviral effect highly similar to that of CQ, could serve as a better therapeutic approach. |
| T6 |
752-878 |
DRI_Approach |
denotes |
HCQ is likely to attenuate the severe progression of COVID-19, inhibiting the cytokine storm by suppressing T cell activation. |
| T7 |
879-954 |
DRI_Challenge |
denotes |
It has a safer clinical profile and is suitable for those who are pregnant. |
| T8 |
955-1005 |
DRI_Approach |
denotes |
It is cheaper and more readily available in China. |
| T9 |
1006-1147 |
DRI_Outcome |
denotes |
We herein strongly urge that clinical trials are performed to assess the preventive effects of HCQ in both disease infection and progression. |
