| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
69-170 |
DRI_Background |
denotes |
Adipose tissue is essential for whole-body glucose homeostasis, with a primary role in lipid storage. |
| T2 |
171-361 |
DRI_Background |
denotes |
It has been previously observed that lactate production is also an important metabolic feature of adipocytes, but its relationship to adipose and whole-body glucose disposal remains unclear. |
| T3 |
362-516 |
DRI_Background |
denotes |
Therefore, using a combination of metabolic labeling techniques, here we closely examined lactate production of cultured and primary mammalian adipocytes. |
| T4 |
517-672 |
DRI_Background |
denotes |
Insulin treatment increased glucose uptake and conversion to lactate, with the latter responding more to insulin than did other metabolic fates of glucose. |
| T5 |
673-928 |
DRI_Challenge |
denotes |
However, lactate production did not just serve as a mechanism to dispose of excess glucose, because we also observed that lactate production in adipocytes did not solely depend on glucose availability and even occurred independently of glucose metabolism. |
| T6 |
929-996 |
DRI_Approach |
denotes |
This suggests that lactate production is prioritized in adipocytes. |
| T7 |
997-1164 |
DRI_Background |
denotes |
Furthermore, knocking down lactate dehydrogenase specifically in the fat body of Drosophila flies lowered circulating lactate and improved whole-body glucose disposal. |
| T8 |
1165-1296 |
DRI_Background |
denotes |
These results emphasize that lactate production is an additional metabolic role of adipose tissue beyond lipid storage and release. |
