PubMed_ArguminSci  

PubMed:31680999 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 138-338 DRI_Background denotes ical interaction between Drosophila melanogaster and its larval parasitoids has been thoroughly investigated, however, little is known about the interaction between the host and its pupal parasitoids.
T2 339-354 REPLACED denotes Pachycrepoideus
T3 365-535 DRI_Approach denotes , a pupal ectoparasitoid of D. melanogaster, injects venom into its host while laying eggs on the puparium, which regulates host immunity and interrupts host development.
T4 536-681 DRI_Background denotes To resist the invasion of parasitic wasps, various immune defense strategies have been developed in their hosts as a consequence of co-evolution.
T5 682-940 DRI_Background denotes In this study, we mainly focused on the host immunomodulation by P. vindemmiae and thoroughly investigated cellular and humoral immune response, including cell adherence, cell viability, hemolymph melanization and the Toll, Imd, and JAK/STAT immune pathways.
T6 941-1071 DRI_Outcome denotes Our results indicated that venom had a significant inhibitory effect on lamellocyte adherence and induced plasmatocyte cell death.
T7 1072-1154 DRI_Background denotes Venom injection and in vitro incubation strongly inhibited hemolymph melanization.
T8 1155-1370 DRI_Background denotes More in-depth investigation revealed that the Toll and Imd immune pathways were immediately activated upon parasitization, followed by the JAK/STAT pathway, which was activated within the first 24 h post-parasitism.
T9 1371-1427 DRI_Background denotes These regulatory effects were further validated by qPCR.
T10 1428-1565 DRI_Outcome denotes Our present study manifested that P. vindemmiae regulated the cellular and humoral immune system of host D. melanogaster in many aspects.
T11 1566-1692 DRI_Background denotes These findings lay the groundwork for studying the immunological interaction between D. melanogaster and its pupal parasitoid.