| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
164-256 |
DRI_Background |
denotes |
The relationship between chemical structure and in vitro cytotoxic activities of a series of |
| T2 |
294-440 |
DRI_Background |
denotes |
(III) halide complexes against cancerous (HepG2, MDA-MB-231, MCF-7 and HeLa) and nonmalignant (HEK-293) cell lines was studied for the first time. |
| T3 |
441-598 |
DRI_Approach |
denotes |
A positive correlation between cytotoxic activity and the length of N→Sb coordinate bond on azastibocine framework of same nitrogen substituent was observed. |
| T4 |
599-828 |
DRI_Approach |
denotes |
By comparison, the organoantimony(III) complex 6-cyclohexyl-12-fluoro-5,6,7,12-tetrahydrodibenzo[c,f][1,5]azastibocine (C4) exhibited the highest selectivity index, giving a IC50(nonmalignant)/IC50(cancerous) ratio of up to 8.33. |
| T5 |
829-987 |
DRI_Outcome |
denotes |
The results of cell cycle analysis indicated that the inhibitory effect of C4 on the cellular viability was caused by cell cycle arrest mainly at the S phase. |
| T6 |
988-1145 |
DRI_Approach |
denotes |
The necrosis induced by C4 was confirmed by the Trypan blue dye exclusion test and the increase of lactic dehydrogenase (LDH) released in the culture medium. |
| T7 |
1146-1409 |
DRI_Background |
denotes |
Furthermore, evaluation of the levels of intracellular reactive oxygen species (ROS) in MDA-MB-231 cells, by quantifying the relative fluorescence units (RFU) using spectrofluorometer, indicated that cytotoxic activity of C4 is dependent on the production of ROS. |
| T8 |
1410-1478 |
DRI_Background |
denotes |
This work established the correlation between cytotoxic activity and |
| T9 |
1502-1657 |
DRI_Background |
denotes |
, a finding that provided theoretical and experimental basis for in-depth design of antimony-based organometallic complexes as potential anticancer agents. |
