| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
120-312 |
DRI_Challenge |
denotes |
Porcine deltacoronavirus (PDCoV) is a newly identified swine enteropathogenic coronavirus that causes watery diarrhea in piglets and results in significant economic losses to the pig industry. |
| T2 |
313-379 |
DRI_Background |
denotes |
Currently there are no effective treatments or vaccines for PDCoV. |
| T3 |
380-456 |
DRI_Background |
denotes |
In particular, the pathogenesis of PDCoV infection is still largely unknown. |
| T4 |
457-555 |
DRI_Outcome |
denotes |
In this study, we reported that inoculating conventional weaned piglets with 1 × 109 TCID50 of the |
| T5 |
574-625 |
DRI_Outcome |
denotes |
strain by oral feeding could cause severe diarrhea. |
| T6 |
626-699 |
DRI_Background |
denotes |
Virus RNA was detected in rectal swabs from 1 to 7 days post inoculation. |
| T7 |
700-863 |
DRI_Outcome |
denotes |
In addition, microscopic lesions in small intestine were observed, and viral antigen also detected in the small intestines with PDCoV immunohistochemical staining. |
| T8 |
864-1153 |
DRI_Outcome |
denotes |
Importantly, PDCoV significantly induced mRNA expression of TLR3, IL-12, IFN-α, IFN-β, and PKR, the genes involved in modulation of the host immune responses, in infected Peyer's patches at 3 d.p.i., indicating that Peyer's patches play an important role in PDCoV immune responses in vivo. |
| T9 |
1154-1321 |
DRI_Outcome |
denotes |
Collectively, our findings suggest that the observed gene expression profile might help explain immunological and pathological changes associated with PDCoV infection. |
