PubMed_ArguminSci  

PubMed:30111851 JSONTXT 15 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 88-188 DRI_Approach denotes Wild birds of Anseriformes and Charadriiformes are natural reservoirs of influenza A viruses (IAVs).
T2 189-305 DRI_Background denotes Occasionally, IAVs transmit and adapt to mammalian hosts, and are maintained as epidemic strains in their new hosts.
T3 306-490 DRI_Background denotes Viral adaptions to mammalian hosts include altered receptor preference of host epithelial sialylated oligosaccharides from terminal α2,3-linked sialic acid (SA) towards α2,6-linked SA.
T4 491-630 DRI_Background denotes However, α2,3-linked SA has been found in human respiratory tract epithelium, and human infections by avian IAVs (AIVs) have been reported.
T5 631-787 DRI_Background denotes To further explore the attachment properties of AIVs, four AIVs of different subtypes were investigated on human and pig tissues using virus histochemistry.
T6 788-903 DRI_Background denotes Additionally, glycan array analysis was performed for further characterization of IAVs' receptor structure tropism.
T7 904-985 DRI_Background denotes Generally, AIV attachment was more abundant to human tissues than to pig tissues.
T8 986-1119 DRI_Background denotes The attachment pattern was very strong to human conjunctiva and upper respiratory tract, but variable to the lower respiratory tract.
T9 1120-1213 DRI_Background denotes AIVs mainly attached to α2,3-linked SA, but also to combinations of α2,3- and α2,6-linked SA.
T10 1214-1443 DRI_Challenge denotes The low attachment of these AIV isolates to pig tissues, but high attachment to human tissues, addresses the question whether AIVs in general require passage through pigs to obtain adaptions towards mammalian receptor structures.