| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
65-146 |
DRI_Background |
denotes |
Polarized epithelial morphogenesis is an essential process in animal development. |
| T2 |
147-265 |
DRI_Background |
denotes |
While this process is mostly attributed to directional cell intercalation, it can also be induced by other mechanisms. |
| T3 |
266-543 |
DRI_Approach |
denotes |
Using live-imaging analysis and a three-dimensional vertex model, we identified 'cell sliding,' a novel mechanism driving epithelial morphogenesis, in which cells directionally change their position relative to their subjacent (posterior) neighbors by sliding in one direction. |
| T4 |
544-829 |
DRI_Outcome |
denotes |
In Drosophila embryonic hindgut, an initial left-right (LR) asymmetry of the cell shape (cell chirality in three dimensions), which occurs intrinsically before tissue deformation, is converted through LR asymmetric cell sliding into a directional axial twisting of the epithelial tube. |
| T5 |
830-984 |
DRI_Background |
denotes |
In a Drosophila inversion mutant showing inverted cell chirality and hindgut rotation, cell sliding occurs in the opposite direction to that in wild-type. |
| T6 |
985-1076 |
DRI_Approach |
denotes |
Unlike directional cell intercalation, cell sliding does not require junctional remodeling. |
| T7 |
1077-1167 |
DRI_Background |
denotes |
Cell sliding may also be involved in other cases of LR-polarized epithelial morphogenesis. |
