| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
132-261 |
DRI_Background |
denotes |
Cytokine signaling is responsible for coordinating conserved epithelial regeneration and immune responses in the digestive tract. |
| T2 |
262-459 |
DRI_Background |
denotes |
In the Drosophila midgut, Upd3 is a major cytokine, which is induced in enterocytes (EC) and enteroblasts (EB) upon oral infection, and initiates intestinal stem cell (ISC) dependent tissue repair. |
| T3 |
460-550 |
DRI_Background |
denotes |
To date, the genetic network directing upd3 transcription remains largely uncharacterized. |
| T4 |
551-693 |
DRI_Outcome |
denotes |
Here, we have identified the key infection-responsive enhancers of the upd3 gene and show that distinct enhancers respond to various stresses. |
| T5 |
694-942 |
DRI_Approach |
denotes |
Furthermore, through functional genetic screening, bioinformatic analyses and yeast one-hybrid screening, we determined that the transcription factors Scalloped (Sd), Mothers against dpp (Mad), and D-Fos are principal regulators of upd3 expression. |
| T6 |
943-1134 |
DRI_Outcome |
denotes |
Our study demonstrates that upd3 transcription in the gut is regulated by the activation of multiple pathways, including the Hippo, TGF-β/Dpp, and Src, as well as p38-dependent MAPK pathways. |
| T7 |
1135-1321 |
DRI_Background |
denotes |
Thus, these essential pathways, which are known to control ISC proliferation cell-autonomously, are also activated in ECs to promote tissue turnover the regulation of upd3 transcription. |
