| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
91-257 |
DRI_Background |
denotes |
Organ fitness depends on appropriate maintenance of stem cell populations, and aberrations in functional stem cell numbers are associated with malignancies and aging. |
| T2 |
258-428 |
DRI_Challenge |
denotes |
Symmetrical division is the best characterized mechanism of stem cell replacement, but other mechanisms could also be deployed, particularly in situations of high stress. |
| T3 |
429-650 |
DRI_Outcome |
denotes |
Here, we show that after severe depletion, intestinal stem cells (ISCs) in the Drosophila midgut are replaced by spindle-independent ploidy reduction of cells in the enterocyte lineage through a process known as amitosis. |
| T4 |
651-800 |
DRI_Challenge |
denotes |
Amitosis is also induced by the functional loss of ISCs coupled with tissue demand and in aging flies, underscoring the generality of this mechanism. |
| T5 |
801-958 |
DRI_Outcome |
denotes |
However, we also found that random homologous chromosome segregation during ploidy reduction can expose deleterious mutations through loss of heterozygosity. |
| T6 |
959-1131 |
DRI_Outcome |
denotes |
Together, our results highlight amitosis as an unappreciated mechanism for restoring stem cell homeostasis, but one with some associated risk in animals carrying mutations. |
