| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
170-290 |
DRI_Background |
denotes |
Apoptosis and DNA oxidative damage serve significant roles in the pathogenesis of steroid‑induced femoral head necrosis. |
| T2 |
358-570 |
DRI_Background |
denotes |
Therefore, the present study investigated the effects of vitamin E on osteocyte apoptosis and DNA oxidative damage in bone marrow hemopoietic cells at an early stage of steroid‑induced femoral head osteonecrosis. |
| T3 |
712-1049 |
DRI_Approach |
denotes |
Those in the steroid group (group S) were initially injected twice with an intravenous dose of 100 µg/kg Escherichia coli endotoxin, with a 24 h interval between the two injections, and then with an intramuscular dose of 20 mg/kg methylprednisolone, three times at intervals of 24 h in order to establish a rabbit model of osteonecrosis. |
| T4 |
1050-1208 |
DRI_Approach |
denotes |
The vitamin E treated group (group E) received the same treatment as group S, and were administered 0.6 g/kg/d vitamin E daily from the beginning of modeling. |
| T5 |
1209-1337 |
DRI_Background |
denotes |
The control group (group C) was injected with normal saline at the equivalent dosage and times as the aforementioned two groups. |
| T6 |
1338-1421 |
DRI_Approach |
denotes |
Two time points, weeks 4 and 6 following the completion of modeling, were selected. |
| T7 |
1500-1619 |
DRI_Background |
denotes |
The apoptosis rate of osteonecrosis was analyzed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay. |
| T8 |
1620-1794 |
DRI_Background |
denotes |
The apoptosis expression levels of caspase‑3 and B‑cell lymphoma 2 (Bcl‑2), and DNA oxidative damage of bone marrow hematopoietic cells were analyzed by immunohistochemistry. |
| T9 |
2396-2701 |
DRI_Outcome |
denotes |
The caspase‑3 staining data at week 4 in femoral head tissues demonstrated that in the 12 femoral heads of group S, four were negative (32%) and eight were positive (68%); in group E, five were negative (45%) and seven were positive (55%); and in group C, 11 were negative (95%) and one was positive (5%). |
| T10 |
2702-2910 |
DRI_Outcome |
denotes |
In addition, the DNA oxidative damage rate at week 4 in the bone marrow hemopoietic cells of group E was (7.24±1.44%), lower compared with group S (11.80±1.26%), and higher compared with group C (5.75±1.47%). |
| T11 |
2911-3005 |
DRI_Approach |
denotes |
Vitamin E is effective in intervening in apoptosis through decreasing caspase‑3 expression and |
| T12 |
3025-3187 |
DRI_Approach |
denotes |
expression, and by alleviating DNA oxidative damage in bone marrow hemopoietic cells at the early stage of steroid‑induced femoral head necrosis in rabbit models. |
