| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
86-205 |
DRI_Background |
denotes |
Antimicrobial properties of a long-chain, synthetic, cationic, and hydrophobic amino acid block copolymer are reported. |
| T2 |
206-524 |
DRI_Outcome |
denotes |
In 5 and 60 min time-kill assays, solutions of K100 L40 block copolymers (poly(l-lysine·hydrochloride)100 -b-poly(l-leucine)40 ) at concentrations of 10-100 µg mL(-1) show multi-log reductions in colony forming units of Gram-positive and Gram-negative bacteria, as well as yeast, including multidrug-resistant strains. |
| T3 |
525-701 |
DRI_Background |
denotes |
Driven by association of hydrophobic segments, K100 L40 copolymers form viscous solutions and self-supporting hydrogels in water at concentrations of 1 and 2 wt%, respectively. |
| T4 |
702-980 |
DRI_Challenge |
denotes |
These K100 L40 preparations provide an effective barrier to microbial contamination of wounds, as measured by multi-log decreases of tissue-associated bacteria with deliberate inoculation of porcine skin explants, porcine open wounds, and rodent closed wounds with foreign body. |
| T5 |
981-1202 |
DRI_Background |
denotes |
Based on these findings, amino acid copolymers with the features of K100 L40 can combine potent, direct antimicrobial activity and barrier properties in one biopolymer for a new approach to prevention of wound infections. |
