PubMed_ArguminSci  

PubMed:27814527 JSONTXT 8 Projects

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Id Subject Object Predicate Lexical cue
T1 151-354 DRI_Background denotes Cyanobacterial blooms threaten human health as well as the population of other living organisms in the aquatic environment, particularly due to the production of natural toxic components, the cyanotoxin.
T2 416-636 DRI_Outcome denotes In this study, the hepatic alterations at histological, proteome and transcriptome levels were evaluated in female and male medaka fish chronically exposed to 1 and 5 μg L(-1) microcystin-LR (MC-LR) and to the extract of
T3 662-863 DRI_Outcome denotes aeruginosa PCC 7820 (5 μg L(-1) of equivalent MC-LR) by balneation for 28 days, aiming at enhancing our understanding of the potential reproductive toxicity of cyanotoxins in aquatic vertebrate models.
T4 864-986 DRI_Outcome denotes Indeed, both MC and Microcystis extract adversely affect reproductive parameters including fecundity and egg hatchability.
T5 987-1077 DRI_Background denotes The liver of toxin treated female fish present glycogen storage loss and cellular damages.
T6 1078-1185 DRI_Background denotes The quantitative proteomics analysis revealed that the quantities of 225 hepatic proteins are dysregulated.
T7 1186-1344 DRI_Background denotes In particular, a notable decrease in protein quantities of vitellogenin and choriogenin was observed, which could explain the decrease in reproductive output.
T8 1345-1532 DRI_Approach denotes Liver transcriptome analysis through Illumina RNA-seq reveals that over 100-400 genes are differentially expressed under 5 μg L(-1) MC-LR and Microcystis extract treatments, respectively.
T9 1533-1802 DRI_Background denotes Ingenuity pathway analysis of the omic data attests that various metabolic pathways, such as energy production, protein biosynthesis and lipid metabolism, are disturbed by both MC-LR and the Microcystis extract, which could provoke the observed reproductive impairment.
T10 1803-1932 DRI_Outcome denotes The transcriptomics analysis also constitutes the first report of the impairment of circadian rhythm-related gene induced by MCs.
T11 1933-2283 DRI_Outcome denotes This study contributes to a better understanding of the potential consequences of chronic exposure of fish to environmental concentrations of cyanotoxins, suggesting that Microcystis extract could impact a wider range of biological pathways, compared with pure MC-LR, and even 1 μg L(-1) MC-LR potentially induces a health risk for aquatic organisms.