PubMed_ArguminSci  

PubMed:27775984 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 100-254 DRI_Background denotes Mafenide acetate is used in some burn wounds for its ability to penetrate eschar but requires frequent uncomfortable dressing changes for its application.
T2 255-502 DRI_Background denotes The authors hypothesize that hydrofiber dressings will hold mafenide acetate solution for an extended period of time and maintain antimicrobial activity longer than traditional gauze, thus possibly obviating the need for frequent dressing changes.
T3 503-830 DRI_Background denotes Four experimental arms included: 1) hydrofiber, stored on a dry well plate as control, 2) gauze saturated with 2.5% mafenide acetate, stored on nonsterile porcine skin, 3) hydrofiber saturated with mafenide acetate, stored on dry well plate, and 4) hydrofiber saturated with mafenide acetate, stored on nonsterile porcine skin.
T4 831-1074 DRI_Outcome denotes At 0, 24, 48, and 72 hours, a 1-cm disk was cut from the dressing sheet of each study arm, placed on agar plates seeded with Staphylococcus aureus and Pseudomonas aeruginosa, and incubated for 24 hours, and the zone of inhibition was measured.
T5 1075-1134 DRI_Background denotes A zone of 2 mm or greater was indicative of susceptibility.
T6 1135-1218 DRI_Approach denotes Each arm of the experiment was performed four times to demonstrate reproducibility.
T7 1219-1351 DRI_Approach denotes Plain hydrofiber (control) demonstrated no zone of inhibition at any time point, thereby possessing no antimicrobial activity alone.
T8 1352-1457 DRI_Outcome denotes Gauze saturated with mafenide acetate did not reliably demonstrate antimicrobial activity beyond 0 hours.
T9 1458-1714 DRI_Outcome denotes Hydrofiber saturated with mafenide acetate, whether stored on a dry well plate or nonsterile porcine skin, consistently possessed sustained antimicrobial activity as demonstrated by zones of inhibition greater than 2 mm to both S. aureus and P. aeruginosa.
T10 1715-1738 REPLACED denotes Mafenide acetate-soaked
T11 1750-1888 DRI_Background denotes dressings stay moist and maintain antimicrobial activity against S. aureus and P. aeruginosa for at least 72 hours without repeated soaks.