PubMed_ArguminSci  

PubMed:26808467 JSONTXT 9 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 141-282 DRI_Approach denotes Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common causes of late onset autosomal dominant form of Parkinson disease (PD).
T2 283-417 DRI_Background denotes Gain of kinase activity due to the substitution of Gly 2019 to Ser (G2019S) is the most common mutation in the kinase domain of LRRK2.
T3 418-526 DRI_Background denotes Genetic predisposition and environmental toxins contribute to the susceptibility of neurodegeneration in PD.
T4 527-805 DRI_Challenge denotes To identify whether the genetic mutations in LRRK2 increase the susceptibility to environmental toxins in PD models, we exposed transgenic mice expressing human G2019S mutant or wild type (WT) LRRK2 to the environmental toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
T5 806-936 DRI_Background denotes MPTP treatment resulted in a greater loss of tyrosine hydroxylase-positive neurons in the substantia nigra pars compacta (SNpc) in
T6 950-1011 DRI_Background denotes transgenic mice compared to the LRRK2 WT overexpressing mice.
T7 1012-1077 DRI_Background denotes Similarly loss of dopamine levels were greater in the striatum of
T8 1091-1164 DRI_Background denotes mice when compared to the LRRK2 WT mice when both were treated with MPTP.
T9 1165-1384 DRI_Background denotes This study suggests a likely interaction between genetic and environmental risk factors in the PD pathogenesis and that the G2019S mutation in LRRK2 increases the susceptibility of dopamine neurons to PD-causing toxins.