| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
132-251 |
DRI_Approach |
denotes |
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most-common genetic determinants of Parkinson's disease (PD). |
| T2 |
252-349 |
DRI_Background |
denotes |
The G2019S mutation is detected most frequently and is associated with increased kinase activity. |
| T3 |
350-485 |
DRI_Challenge |
denotes |
Whereas G2019S mutant dopamine neurons exhibit neurite elongation deficits, the effect of G2019S on other neuronal subtypes is unknown. |
| T4 |
486-711 |
DRI_Challenge |
denotes |
As PD patients also suffer from non-motor symptoms that may be unrelated to dopamine neuron loss, we used induced pluripotent stem cells (iPSCs) to assess morphological and functional properties of peripheral sensory neurons. |
| T5 |
712-724 |
REPLACED |
denotes |
LRRK2 G2019S |
| T6 |
738-844 |
DRI_Background |
denotes |
sensory neurons exhibited normal neurite length but had large microtubule-containing neurite aggregations. |
| T7 |
845-858 |
DRI_Background |
denotes |
Additionally, |
| T8 |
885-936 |
DRI_Background |
denotes |
sensory neurons displayed altered calcium dynamics. |
| T9 |
937-1055 |
DRI_Background |
denotes |
Treatment with LRRK2 kinase inhibitors resulted in significant, but not complete, morphological and functional rescue. |
| T10 |
1056-1215 |
DRI_Challenge |
denotes |
These data indicate a role for LRRK2 kinase activity in sensory neuron structure and function, which when disrupted, may lead to sensory neuron deficits in PD. |
