| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
124-446 |
DRI_Challenge |
denotes |
As the mechanisms underlying PKC activation induced arrhythmias are not yet fully verified, we investigated the role of gap junctions in arrhythmias induced by PKC activation.Arterially-perfused rabbit left ventricular preparations were randomly assigned to perfusion with phorbol ester (PMA) or in combination with AAP10. |
| T2 |
447-584 |
DRI_Outcome |
denotes |
Transmural ECG as well as action potentials from both endocardium and epicardium were simultaneously recorded throughout all experiments. |
| T3 |
585-617 |
DRI_Background |
denotes |
Changes in connexin43 (Cx43) and |
| T4 |
641-918 |
DRI_Background |
denotes |
on S368 were measured by Western blot analysis.In the PMA group, the QT interval was shortened, the interval from the peak to the end of the electrocardiographic T wave (Tp-e) and induced nonsustained ventricular tachycardia (VT) were increased, and the expressions of Cx43 and |
| T5 |
942-997 |
DRI_Background |
denotes |
on S368 were decreased compared with the control group. |
| T6 |
998-1095 |
DRI_Outcome |
denotes |
Compared with the PMA group, without significant changes in the QT interval and the expression of |
| T7 |
1125-1207 |
DRI_Outcome |
denotes |
on S368, Tp-e and induced VT decreased and the expression of Cx43 increased in the |
| T8 |
1226-1356 |
DRI_Outcome |
denotes |
can prevent PMA-induced rabbit ventricular arrhythmias by attenuating the increase of Tp-e and the decrease of expression of Cx43. |
| T9 |
1357-1474 |
DRI_Background |
denotes |
These data suggest that increasing gap junction coupling prevents arrhythmias induced by protein kinase C activation. |
