PubMed_ArguminSci  

PubMed:25503524 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 65-204 DRI_Background denotes Arteries often endure axial twist due to body movement and surgical procedures, but how arteries remodel under axial twist remains unclear.
T2 205-307 DRI_Background denotes The objective of this study was to investigate early stage arterial wall remodeling under axial twist.
T3 308-485 DRI_Background denotes Porcine carotid arteries were twisted axially and maintained for three days in ex vivo organ culture systems while the pressure and flow remained the same as untwisted controls.
T4 486-816 DRI_Outcome denotes Cell proliferation, internal elastic lamina (IEL) fenestrae shape and size, endothelial cell (EC) morphology and orientation, as well as the expression of matrix metalloproteinases (MMPs), MMP-2 and MMP-9, and tissue inhibitor of metalloproteinase-2 (TIMP-2) were quantified using immunohistochemistry staining and immunoblotting.
T5 817-970 DRI_Outcome denotes Our results demonstrated that cell proliferation in both the intima and media were significantly higher in the twisted arteries compared to the controls.
T6 971-1115 DRI_Outcome denotes The cell proliferation in the intima increased from 1.33 ± 0.21% to 7.63 ± 1.89%, and in the media from 1.93 ± 0.84% to 8.27 ± 2.92% (p < 0.05).
T7 1364-1491 DRI_Approach denotes MMP-2 expression significantly increased (p < 0.05) while MMP-9 and TIMP-2 showed no significant difference in the twist group.
T8 1492-1595 DRI_Approach denotes The ECs in the twisted arteries were significantly elongated compared to the controls after three days.
T9 1596-1778 DRI_Approach denotes The angle between the major axis of the ECs and blood flow direction under twist was 7.46 ± 2.44 degrees after 3 days organ culture, a decrease from the initial 15.58 ± 1.29 degrees.
T10 1779-1854 DRI_Outcome denotes These results demonstrate that axial twist can stimulate artery remodeling.
T11 1855-1995 DRI_Outcome denotes These findings complement our understanding of arterial wall remodeling under mechanical stress resulting from pressure and flow variations.