PubMed_ArguminSci  

PubMed:25174649 JSONTXT 15 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 144-360 DRI_Background denotes Mutations in leucine-rich repeated kinase 2 (LRRK2) cause autosomal dominant late-onset Parkinson's disease (PD), and the G2019S mutation in the kinase domain of LRRK2 is the most common genetic cause of familial PD.
T2 361-388 DRI_Background denotes Enhanced kinase activity of
T3 402-488 DRI_Background denotes is a suspected mechanism for carriers to develop PD but pathophysiological function of
T4 502-515 DRI_Background denotes is not clear.
T5 516-625 DRI_Background denotes The objective of the present study was to characterize a bacterial artificial chromosome rat expressing human
T6 638-639 DRI_Background denotes .
T7 640-675 DRI_Outcome denotes Immunoblotting analysis showed that
T8 689-760 DRI_Outcome denotes expression was approximately 5-8 times higher than wild-type rat LRRK2.
T9 761-839 DRI_Outcome denotes At ages of 4, 8, and 12 months, our characterization showed that expression of
T10 853-1171 DRI_Outcome denotes induced oxidative stress in striatum and substantia nigra, increased inducible nitric oxide synthase expression in nigral dopamine neurons, and abnormal morphology of nigral dopaminergic neurons in transgenic rats compared with wild-type, without inducing overt neurodegeneration in nigrostriatal dopaminergic neurons.
T11 1172-1430 DRI_Challenge denotes Thus, we conclude that although this model does not reproduce the key features of end-stage PD, important preclinical features of the disease are evident, which may be useful in studying the earliest stages of PD and for gene-environment interaction studies.