PubMed_ArguminSci  

PubMed:25156158 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 107-122 DRI_Approach denotes The Frog Embryo
T2 151-222 DRI_Approach denotes (FETAX) was used to assess the teratogenic potential of two tocolytics.
T3 223-321 DRI_Background denotes Embryos of the South African clawed frog, Xenopus laevis, were exposed to ritodrine or nifedipine.
T4 322-385 DRI_Background denotes Exposure media were changed and monitored at 24-hour intervals.
T5 653-839 DRI_Outcome denotes Nifedipine was determined to be the more toxic and teratogenic than ritodrine, with a LC50 of 0.606 µg/L, an EC50 of 0.006 µg/L, and a teratogenicity Index (TI) value (LC50/EC50) of 101.
T6 840-897 DRI_Outcome denotes On the other hand, the LC50 of ritodrine was 28.571 mg/L.
T7 898-1073 DRI_Background denotes In addition; the LC50, EC50 and TI values for nifedipine in the 5 mg/L ritodrine + nifedipine combination group were determined as 1.050 µg/L, 0.868 µg/L and 1.5 respectively.
T8 1074-1167 DRI_Approach denotes For ritodrine, the NOAEC and LOAEC values were determined as 2 mg/L and 4 mg/L, respectively.
T9 1168-1309 DRI_Background denotes For the nifedipine and the ritodrine + nifedipine groups; while the LOAEC values of these groups were 0.0001 µg/L and 0.1 µg/L, respectively.
T10 1310-1345 DRI_Approach denotes NOAEC value couldn't be determined.
T11 1346-1469 DRI_Outcome denotes Our results demonstrated that nifedipine administration was associated with higher levels of teratogenic and toxic effects.
T12 1470-1598 DRI_Background denotes However, the ritodrine + nifedipine combination form reduced the toxic and teratogenic effects of nifedipine on Xenopus embryos.
T13 1599-1753 DRI_Approach denotes Further studies should be conducted in order to investigate the optimal combination concentrations of these substances for the treatment of preterm labor.