PubMed_ArguminSci  

PubMed:24037315 JSONTXT 76 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T1 102-246 DRI_Outcome denotes Bisected, complex N-glycans on glycoproteins are generated by the glycosyltransferase MGAT3 and cause reduced cell surface binding of galectins.
T2 247-480 DRI_Outcome denotes Previously, we showed that MGAT3 reduces growth factor signaling and retards mammary tumor progression driven by the Polyoma middle T antigen (PyMT) expressed in mammary epithelium under the mouse mammary tumor virus (MMTV) promoter.
T3 481-614 DRI_Background denotes However, the penetrance of the tumor phenotype became variable in mixed FVB/N and C57BL/6 female mice and we therefore investigated a
T4 637-659 DRI_Background denotes (-/-)/MMTV-PyMT model.
T5 660-684 DRI_Challenge denotes In the absence of MGAT3,
T6 698-834 DRI_Challenge denotes (-/-)/MMTV-PyMT females exhibited accelerated tumor appearance and increased tumor burden, glucose uptake in tumors and lung metastasis.
T7 835-950 DRI_Outcome denotes Nevertheless, activation of extracellular signal-regulated kinase (ERK)1/2 or protein kinase B (AKT) was reduced in
T8 978-999 DRI_Outcome denotes tumors lacking MGAT3.
T9 1000-1146 DRI_Background denotes Activation of focal adhesion kinase (FAK), protein tyrosine kinase Src, and p38 mitogen-activated protein kinase were similar to that of controls.
T10 1147-1378 DRI_Approach denotes All the eight mouse galectin genes were expressed in mammary tumors and tumor epithelial cells (TECs), but galectin-2 and -12 were not detected by western analysis in tumors, and galectin-7 was not detected in 60% of the TEC lines.
T11 1379-1461 DRI_Outcome denotes From microarray data reported for human breast cancers, at least 10 galectin and 7
T12 1492-1640 DRI_Outcome denotes (GlcNAc)-transferase (MGAT) genes are expressed in tumor tissue, and expression often varies significantly between different breast cancer subtypes.
T13 1641-2077 DRI_Challenge denotes Thus, in summary, while MGAT3 and bisected complex N-glycans retard mouse mammary tumor progression, genetic background may modify this effect; identification of key galectins that promote mammary tumor progression in mice is not straightforward because all the eight galectin genes are expressed; and high levels of MGAT3, galectin-4, -8, -10, -13 and -14 transcripts correlate with better relapse-free survival in human breast cancer.