PubMed_ArguminSci  

PubMed:23435948 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 95-353 DRI_Outcome denotes As a part of our ongoing effort to identify anti-diabetic constituents from natural sources, we examined the inhibitory activity of the methanol extracts of 12 species of the genus Artemisia, against α-glucosidase and protein tyrosine phosphatase 1B (PTP1B).
T2 354-463 DRI_Background denotes The methanol extracts of different species exhibited promising α-glucosidase and PTP1B inhibitory activities.
T3 464-666 DRI_Background denotes Since the methanol extract of Artemisia capillaris exhibited the highest α-glucosidase inhibitory activity together with significant PTP1B inhibitory activity, it was selected for further investigation.
T4 667-873 DRI_Background denotes Repeated column chromatography based on bioactivity guided fractionation yielded 10 coumarins (esculetin, esculin, scopolin, isoscopolin, daphnetin, umbelliferone, 7-methoxy coumarin, scoparone, scopoletin,
T5 896-975 DRI_Background denotes C), 8 flavonoids (hyperoside, quercetin, isorhamnetin, cirsilineol, arcapillin,
T6 1004-1014 DRI_Background denotes , linarin,
T7 1040-1269 DRI_Background denotes ), 6 phenolic compounds (1,5-dicaffeoylquinic acid, 3,4-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid, 3,5-dicaffeoylquinic acid methyl ester, 4,5-dicaffeoylquinic acid, 3-caffeoylquinic acid), and one chromone (capillarisin).
T8 1270-1548 DRI_Background denotes Among these compounds, esculetin, scopoletin, quercetin, hyperoside, isorhamnetin, 3,5-dicaffeoylquinic acid methyl ester, 3,4-dicaffeoylquinic acid, and 1,5-dicaffeoylquinic acid exhibited potent α-glucosidase inhibitory activity when compared to the positive control acarbose.
T9 1549-1575 DRI_Background denotes In addition, esculetin and
T10 1598-1636 DRI_Background denotes C displayed PTP1B inhibitory activity.
T11 1637-1733 DRI_Outcome denotes Interestingly, all isolated dicaffeoylquinic acids showed significant PTP1B inhibitory activity.
T12 1734-1876 DRI_Outcome denotes Therefore, the results of the present study clearly demonstrate the potential of the A. capillaris extract to inhibit α-glucosidase and PTP1B.
T13 1877-2149 DRI_Background denotes These inhibitory properties can be largely attributed to a combination of different chemical structures, including coumarins, flavonoids, and dicaffeoylquinic acids, which could be further explored to develop therapeutic or preventive agents for the treatment of diabetes.