| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
95-261 |
DRI_Approach |
denotes |
Mutations in leucine-rich repeat kinase 2 (LRRK2) are a major cause of familial Parkinsonism, and the G2019S mutation of LRRK2 is one of the most prevalent mutations. |
| T2 |
262-380 |
DRI_Challenge |
denotes |
The deregulation of autophagic processes in nerve cells is thought to be a possible cause of Parkinson's disease (PD). |
| T3 |
381-508 |
DRI_Outcome |
denotes |
In this study, we observed that G2019S mutant fibroblasts exhibited higher autophagic activity levels than control fibroblasts. |
| T4 |
509-676 |
DRI_Background |
denotes |
Elevated levels of autophagic activity can trigger cell death, and in our study, G2019S mutant cells exhibited increased apoptosis hallmarks compared to control cells. |
| T5 |
677-747 |
DRI_Background |
denotes |
LRRK2 is able to induce the phosphorylation of MAPK/ERK kinases (MEK). |
| T6 |
748-926 |
DRI_Background |
denotes |
The use of 1,4-diamino-2,3-dicyano-1,4-bis[2-aminophenylthio]butadiene (U0126), a highly selective inhibitor of MEK1/2, reduced the enhanced autophagy and sensibility observed in |
| T7 |
940-955 |
DRI_Background |
denotes |
mutation cells. |
| T8 |
956-1148 |
DRI_Outcome |
denotes |
These data suggest that the G2019S mutation induces autophagy via MEK/ERK pathway and that the inhibition of this exacerbated autophagy reduces the sensitivity observed in G2019S mutant cells. |
