| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
93-236 |
DRI_Background |
denotes |
Ductal carcinoma in situ (DCIS) of the breast is a non-invasive tumor in which cells proliferate abnormally, but remain confined within a duct. |
| T2 |
237-462 |
DRI_Background |
denotes |
Although four distinguishable DCIS morphologies are recognized, the mechanisms that generate these different morphological classes remain unclear, and consequently the prognostic strength of DCIS classification is not strong. |
| T3 |
463-642 |
DRI_Challenge |
denotes |
To improve the understanding of the relation between morphology and time course, we have developed a 2D in silico particle model of the growth of DCIS within a single breast duct. |
| T4 |
643-824 |
DRI_Background |
denotes |
This model considers mechanical effects such as cellular adhesion and intra-ductal pressure, and biological features including proliferation, apoptosis, necrosis, and cell polarity. |
| T5 |
825-1006 |
DRI_Outcome |
denotes |
Using this model, we find that different regions of parameter space generate distinct morphological subtypes of DCIS, so elucidating the relation between morphology and time course. |
| T6 |
1007-1215 |
DRI_Outcome |
denotes |
Furthermore, we find that tumors with similar architectures may in fact be produced through different mechanisms, and we propose future work to further disentangle the mechanisms involved in DCIS progression. |
