| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
95-236 |
DRI_Background |
denotes |
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with a prevalence of more than 1% after the age of 65 years. |
| T2 |
237-438 |
DRI_Background |
denotes |
Mutations in the gene encoding leucine-rich repeat kinase-2 (LRRK2) have recently been linked to autosomal dominant, late-onset PD that is clinically indistinguishable from typical, idiopathic disease. |
| T3 |
439-590 |
DRI_Background |
denotes |
LRRK2 is a multidomain protein containing several protein interaction motifs as well as dual enzymatic domains of GTPase and protein kinase activities. |
| T4 |
591-682 |
DRI_Background |
denotes |
Disease-associated mutations are found throughout the multidomain structure of the protein. |
| T5 |
683-842 |
DRI_Background |
denotes |
LRRK2, however, is unique among the PD-causing genes, because a missense mutation, G2019S, is a frequent determinant of not only familial but also sporadic PD. |
| T6 |
843-918 |
DRI_Challenge |
denotes |
Thus, LRRK2 has emerged as a promising therapeutic target for combating PD. |
| T7 |
919-1080 |
DRI_Challenge |
denotes |
In this Mini-Review, we look at the current state of knowledge regarding the domain structure, amino acid substitutions, and potential functional roles of LRRK2. |
