PubMed_ArguminSci  

PubMed:15932919 JSONTXT 48 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 102-218 DRI_Background denotes Cell surface carbohydrates expressed on epithelial cells are thought to play an important role in tumor progression.
T2 219-268 DRI_Outcome denotes Previously, we have shown that expression of core
T3 290-384 DRI_Outcome denotes is closely correlated with vessel invasion and depth of invasion in colon and lung carcinomas.
T4 385-571 DRI_Outcome denotes In this study, we found that expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1, Core2GnT, is positively correlated with the progression of prostate cancer in human patients.
T5 572-736 DRI_Challenge denotes Statistical analysis demonstrated that Core2GnT is an independent predictor for progressed pathological stage (pT3) and for prostate-specific antigen (PSA) relapse.
T6 737-893 DRI_Approach denotes To determine directly the roles of Core2GnT in prostate cancer progression, we set up an experimental tumor model using the LNCaP prostate cancer cell line.
T7 894-1051 DRI_Approach denotes Because this line does not express Core2GnT, we established an LNCaP line stably expressing Core2GnT, LNCap-Core2GnT, by transfecting cDNA encoding Core2GnT.
T8 1052-1056 DRI_Background denotes When
T9 1080-1221 DRI_Background denotes cells and LNCaP-Core2GnT were inoculated in the prostate of nude mice, LNCaP-Core2GnT cells produced three times heavier prostate tumors than
T10 1245-1251 DRI_Background denotes cells.
T11 1252-1519 DRI_Approach denotes Furthermore, we found that LNCaP-Core2GnT cells adhered more strongly to prostate stromal cells, type IV collagen and laminin than did LNCaP-mock cells, but LNCaP and LNCaP-Core2GnT cells grew almost at the same rate on plates coated with type IV collagen or laminin.
T12 1520-1630 DRI_Outcome denotes These results indicate that Core2GnT is an extremely useful prognostic marker for prostate cancer progression.
T13 1631-1881 DRI_Background denotes The results also suggest that acquiring Core2GnT in prostate carcinoma cells facilitates adhesion to type IV collagen and laminin, and this increased adhesion may be a cause for aggressive tumor formation by prostate cancer cells expressing Core2GnT.