PubMed_ArguminSci  

PubMed:12907692 JSONTXT 58 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T1 164-274 DRI_Outcome denotes Lambs respond to vaccination against bacteria and viruses but have a poor immunological response to nematodes.
T2 275-344 DRI_Approach denotes Here we report that they are protected against the parasitic nematode
T3 366-460 DRI_Approach denotes after vaccination with excretory/secretory (ES) glycoproteins using Alhydrogel as an adjuvant.
T4 461-683 DRI_Outcome denotes Lambs immunized with ES in Alhydrogel and challenged with 300 L3 larvae/kg body weight had a reduction in cumulative egg output of 89% and an increased percentage protection of 54% compared with the adjuvant control group.
T5 684-856 DRI_Background denotes Compared to the adjuvant dimethyl dioctadecyl ammonium bromide, Alhydrogel induced earlier onset and significantly higher ES- specific IgG, IgA, and IgE antibody responses.
T6 857-1004 DRI_Approach denotes In all vaccinated groups a substantial proportion of the antibody response was directed against glycan epitopes, irrespective of the adjuvant used.
T7 1005-1173 DRI_Outcome denotes In lambs vaccinated with ES in Alhydrogel but not in any other group a significant increase was found in antibody levels against the GalNAcbeta1,4 (Fucalpha1,3)GlcNAc (
T8 1193-1322 DRI_Outcome denotes , LDNF) antigen, a carbohydrate antigen that is also involved in the host defense against the human parasite Schistosoma mansoni.
T9 1323-1452 DRI_Outcome denotes In lambs the LDNF-specific response increased from the first immunization onward and was significantly higher in protected lambs.
T10 1453-1558 DRI_Background denotes In addition, an isotype switch from LDNF-specific IgM to IgG was induced that correlated with protection.
T11 1559-1748 DRI_Approach denotes These data demonstrate that hyporesponsiveness of lambs to H. contortus can be overcome by vaccination with ES glycoproteins in a strong T-helper 2 type response-inducing aluminum adjuvant.
T12 1749-1882 DRI_Outcome denotes This combination generated high and specific antiglycan antibody responses that may contribute to the vaccination-induced protection.