PubMed_ArguminSci  

PubMed:10945637 JSONTXT 7 Projects

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Id Subject Object Predicate Lexical cue
T1 117-237 DRI_Challenge denotes Fibroblast growth factors (FGFs) are known to play an important role in the growth of normal prostatic epithelial cells.
T2 238-426 DRI_Background denotes In addition to their effects on proliferation, FGFs can promote cell motility, increase tumor angiogenesis, and inhibit apoptosis, all of which play an important role in tumor progression.
T3 427-672 DRI_Challenge denotes To determine whether FGFs are overexpressed in human prostate cancers, we analyzed 26 prostate cancer RNAs by reverse transcription-PCR for expression of FGF3, FGF4, and FGF6, which cannot be detected in normal prostate tissue by this technique.
T4 673-725 DRI_Background denotes Fourteen of 26 prostate cancers expressed FGF6 mRNA.
T5 726-769 DRI_Background denotes No expression of FGF3 or FGF4 was detected.
T6 770-1058 DRI_Background denotes An ELISA of tissue extracts of normal prostate, high-grade prostatic intraepithelial neoplasia (PIN), and prostate cancer for FGF6 showed that this growth factor was undetectable in normal prostate but was present at elevated levels in 4 of 9 PIN lesions and in 15 of 24 prostate cancers.
T7 1059-1213 DRI_Background denotes Immunohistochemical analysis with anti-FGF6 antibody revealed weak staining of prostatic basal cells in normal prostate that was markedly elevated in PIN.
T8 1214-1329 DRI_Background denotes In the prostate cancers, the majority of cases revealed expression of FGF6 by the prostate cancer cells themselves.
T9 1330-1394 DRI_Background denotes In two cases, expression was present in prostatic stromal cells.
T10 1395-1587 DRI_Background denotes Exogenous FGF6 was able to stimulate proliferation of primary prostatic epithelial and stromal cells, immortalized prostatic epithelial cells, and prostate cancer cell lines in tissue culture.
T11 1588-1733 DRI_Outcome denotes FGF receptor 4, which is the most potent FGF receptor for FGF6, is expressed in the human prostate in vivo and in all of the cultured cell lines.
T12 1734-1904 DRI_Background denotes Thus, FGF6 is increased in PIN and prostate cancer and can promote the proliferation of the transformed prostatic epithelial cells via paracrine and autocrine mechanisms.