| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-99 |
Sentence |
denotes |
BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II. |
| T2 |
100-261 |
Sentence |
denotes |
Bone morphogenetic protein-2 (BMP-2) induces bone formation and regeneration in adult vertebrates and regulates important developmental processes in all animals. |
| T3 |
262-477 |
Sentence |
denotes |
BMP-2 is a homodimeric cysteine knot protein that, as a member of the transforming growth factor-beta (TGF-beta) superfamily, signals by oligomerizing type I and type II receptor serine-kinases in the cell membrane. |
| T4 |
478-664 |
Sentence |
denotes |
The binding epitopes of BMP-2 for BMPR-IA (type I) and BMPR-II or ActR-II (type II) were characterized using BMP-2 mutant proteins for analysis of interactions with receptor ectodomains. |
| T5 |
665-772 |
Sentence |
denotes |
A large epitope 1 for high-affinity BMPR-IA binding was detected spanning the interface of the BMP-2 dimer. |
| T6 |
773-895 |
Sentence |
denotes |
A smaller epitope 2 for the low-affinity binding of BMPR-II was found to be assembled by determinants of a single monomer. |
| T7 |
896-977 |
Sentence |
denotes |
Symmetry-related pairs of the two juxtaposed epitopes occur near the BMP-2 poles. |
| T8 |
978-1177 |
Sentence |
denotes |
Mutations in both epitopes yielded variants with reduced biological activity in C2C12 cells; however, only epitope 2 variants behaved as antagonists partially or completely inhibiting BMP-2 activity. |
| T9 |
1178-1314 |
Sentence |
denotes |
These findings provide a framework for the molecular description of receptor recognition and activation in the BMP/TGF-beta superfamily. |
