| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-112 |
Sentence |
denotes |
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. |
| T2 |
113-323 |
Sentence |
denotes |
Crosslinking of immunoreceptor tyrosine-based activation motif (ITAM)-containing receptor complexes on a variety of cells leads to their activation through the sequential triggering of protein tyrosine kinases. |
| T3 |
324-505 |
Sentence |
denotes |
Recently, DAP12 has been identified as an ITAM-bearing signaling molecule that is noncovalently associated with activating isoforms of MHC class I receptors on natural killer cells. |
| T4 |
506-699 |
Sentence |
denotes |
In addition to natural killer cells, DAP12 is expressed in peripheral blood monocytes, macrophages, and dendritic cells, suggesting association with other receptors present in these cell types. |
| T5 |
700-894 |
Sentence |
denotes |
In the present study, we report the molecular cloning of the myeloid DAP12-associating lectin-1 (MDL-1), a DAP12-associating membrane receptor expressed exclusively in monocytes and macrophages. |
| T6 |
895-1073 |
Sentence |
denotes |
MDL-1 is a type II transmembrane protein belonging to the C type lectin superfamily and contains a charged residue in the transmembrane region that enables it to pair with DAP12. |
| T7 |
1074-1176 |
Sentence |
denotes |
Crosslinking of MDL-1/DAP12 complexes in J774 mouse macrophage cells resulted in calcium mobilization. |
| T8 |
1177-1306 |
Sentence |
denotes |
These findings suggest that signaling via MDL-1/DAP12 complexes may constitute a significant activation pathway in myeloid cells. |
