| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-112 |
Sentence |
denotes |
NF-kappaB-mediated up-regulation of Bcl-x and Bfl-1/A1 is required for CD40 survival signaling in B lymphocytes. |
| T2 |
113-227 |
Sentence |
denotes |
Activation of CD40 is essential for thymus-dependent humoral immune responses and rescuing B cells from apoptosis. |
| T3 |
228-316 |
Sentence |
denotes |
Many of the effects of CD40 are believed to be achieved through altered gene expression. |
| T4 |
317-469 |
Sentence |
denotes |
In addition to Bcl-x, a known CD40-regulated antiapoptotic molecule, we identified a related antiapoptotic molecule, A1/Bfl-1, as a CD40-inducible gene. |
| T5 |
470-712 |
Sentence |
denotes |
Inhibition of the NF-kappaB pathway by overexpression of a dominant-active inhibitor of NF-kappaB abolished CD40-induced up-regulation of both the Bfl-1 and Bcl-x genes and also eliminated the ability of CD40 to rescue Fas-induced cell death. |
| T6 |
713-866 |
Sentence |
denotes |
Within the upstream promoter region of Bcl-x, a potential NF-kappaB-binding sequence was found to support NF-kappaB-dependent transcriptional activation. |
| T7 |
867-1008 |
Sentence |
denotes |
Furthermore, expression of physiological levels of Bcl-x protected B cells from Fas-mediated apoptosis in the absence of NF-kappaB signaling. |
| T8 |
1009-1143 |
Sentence |
denotes |
Thus, our results suggest that CD40-mediated cell survival proceeds through NF-kappaB-dependent up-regulation of Bcl-2 family members. |
