| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-120 |
Sentence |
denotes |
Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. |
| T2 |
121-292 |
Sentence |
denotes |
We searched for proteins that interact with Ras in interleukin (IL)-2-stimulated or IL-2-deprived cells, and found that the transcription factor Aiolos interacts with Ras. |
| T3 |
293-381 |
Sentence |
denotes |
The Ras-Aiolos interaction was confirmed in vitro and in vivo by co-immunoprecipitation. |
| T4 |
382-548 |
Sentence |
denotes |
Indirect immunofluorescence shows that IL-2 controls the cellular distribution of Aiolos and induces its tyrosine phosphorylation, required for dissociation from Ras. |
| T5 |
549-679 |
Sentence |
denotes |
We also identified functional Aiolos-binding sites in the Bcl-2 promoter, which are able to activate the luciferase reporter gene. |
| T6 |
680-853 |
Sentence |
denotes |
Mutation of Aiolos-binding sites within the Bcl-2 promoter inhibits transactivation of the reporter gene luciferase, suggesting direct control of Bcl-2 expression by Aiolos. |
| T7 |
854-973 |
Sentence |
denotes |
Co-transfection experiments confirm that Aiolos induces Bcl-2 expression and prevents apoptosis in IL-2-deprived cells. |
| T8 |
974-1043 |
Sentence |
denotes |
We propose a model for the regulation of Bcl-2 expression via Aiolos. |
