| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-162 |
Sentence |
denotes |
Glycoprotein reglucosylation and nucleotide sugar utilization in the secretory pathway: identification of a nucleoside diphosphatase in the endoplasmic reticulum. |
| T2 |
163-333 |
Sentence |
denotes |
UDP is generated in the lumen of the endoplasmic reticulum (ER) as a product of the UDP-glucose-dependent glycoprotein reglucosylation in the calnexin/calreticulin cycle. |
| T3 |
334-448 |
Sentence |
denotes |
We describe here the identification, purification and characterization of an ER enzyme that hydrolyzes UDP to UMP. |
| T4 |
449-611 |
Sentence |
denotes |
This nucleoside diphosphatase is a ubiquitously expressed, soluble 45 kDa glycoprotein devoid of transmembrane domains and KDEL-related ER localization sequences. |
| T5 |
612-771 |
Sentence |
denotes |
It requires divalent cations for activity and hydrolyzes UDP, GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. |
| T6 |
772-985 |
Sentence |
denotes |
By eliminating UDP, which is an inhibitory product of the UDP-Glc:glycoprotein glucosyltransferase, it is likely to promote reglucosylation reactions involved in glycoprotein folding and quality control in the ER. |
