| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-120 |
Sentence |
denotes |
SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. |
| T2 |
121-334 |
Sentence |
denotes |
T lymphocytes express several low molecular weight transmembrane adaptor proteins that recruit src homology (SH)2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling motifs. |
| T3 |
335-443 |
Sentence |
denotes |
We describe here a novel molecule of this group termed SIT (SHP2 interacting transmembrane adaptor protein). |
| T4 |
444-528 |
Sentence |
denotes |
SIT is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes. |
| T5 |
529-728 |
Sentence |
denotes |
After tyrosine phosphorylation by src and possibly syk protein tyrosine kinases SIT recruits the SH2 domain-containing tyrosine phosphatase SHP2 via an immunoreceptor tyrosine-based inhibition motif. |
| T6 |
729-1000 |
Sentence |
denotes |
Overexpression of SIT in Jurkat cells downmodulates T cell receptor- and phytohemagglutinin-mediated activation of the nuclear factor of activated T cells (NF-AT) by interfering with signaling processes that are probably located upstream of activation of phospholipase C. |
| T7 |
1001-1217 |
Sentence |
denotes |
However, binding of SHP2 to SIT is not required for inhibition of NF-AT induction, suggesting that SIT not only regulates NF-AT activity but also controls NF-AT unrelated pathways of T cell activation involving SHP2. |
