LitCovid-sentences  

PubMed:33173837 JSONTXT 24 Projects

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Id Subject Object Predicate Lexical cue
T1 0-62 Sentence denotes New putative animal reservoirs of SARS-CoV-2 in Italian fauna:
T2 63-88 Sentence denotes A bioinformatic approach.
T3 89-227 Sentence denotes SARS-CoV-2 is a virus belonging to the betacoronavirus family, causing fatal respiratory disease in humans, which became pandemic in 2020.
T4 228-322 Sentence denotes Italy is one of the most affected countries by COVID-19, particularly in the northern regions.
T5 323-563 Sentence denotes Several studies consider COVID-19 a zoonotic disease and, since Italy is the repository of a high biodiversity, SARS-CoV-2 infection in animals can be considered as a reservoir of the virus or favor the spreading between animals and humans.
T6 564-693 Sentence denotes In this work, we analyzed the amino acid sequences of ACE2 protein of the most common domestic and wild animals present in Italy.
T7 694-823 Sentence denotes Among the latter, we focused on ACE2 of the Chiroptera species present in Italy to identify the primary reservoir in this region.
T8 824-1010 Sentence denotes First, we reproduced in silico the Chiroptera ACE2/viral spike (S) protein interactions on the human ACE2/SARS-CoV-2 S complex model and identified the critical residues for the binding.
T9 1011-1213 Sentence denotes In silico molecular docking of ACE2 belonging to Chiroptera vs SARS-CoV-2 S protein pointed to Rhinolophus ferrumequinum as a bat living in Italy, that may be a potential primary reservoir of the virus.
T10 1214-1474 Sentence denotes On the other hand, a sequence similarity search on ACE2 of domestic and wild animals living in Italy pointed to domestic (horses, cats, cattle and sheep) and wild (European rabbits and grizzly bears) animal species as potential SARS-CoV-2 secondary reservoirs.
T11 1475-1777 Sentence denotes Molecular docking of ACE2 belonging to these species vs S protein of Bat coronavirus (Bt-CoV/Rp3/2004) suggests that the primary reservoir Rhinolophus ferrumequinum may infect the secondary reservoirs, domestic and worldwide animals living in Italy, determining a specific risk of SARS-CoV-2 infection.